Greek seventh seed Stefanos Tsitsipas, tipped by many as a potential Wimbledon champion, crashed out in the first round on Monday.
The 20-year-old lost 6-4, 3-6, 6-4, 6-7 (8/10), 6-3 to world number 89 Thomas Fabbiano of Italy who next faces 40-year-old Ivo Karlovic.
Cori Gauff, at 15 the youngest ever qualifier for the Wimbledon singles, pulled off a major shock on Monday beating five-time champion Venus Williams 6-4, 6-4 in their first round clash.
The teenage American — who was not even born when Williams had won her first two Wimbledon singles titles — showed not an ounce of fear on Court One and made light of the 24 years age difference.
Key results from Day 1
Men’s
Novak Djokovic (SRB x1) bt Philipp Kohlschreiber (GER) 6-3, 7-5, 6-3
Kevin Anderson (RSA x4) bt Pierre-Hugues Herbert (FRA) 6-3, 6-4, 6-2
Stan Wawrinka (SUI x22) bt Ruben Bemelmans (BEL) 6-3, 6-2, 6-2
Milos Raonic (CAN x15) bt Prajnesh Gunneswaran (IND) 7-6 (7/1), 6-4, 6-2
Jirí Veselý (CZE) bt Alexander Zverev (GER x6) 4-6, 6-3, 6-2, 7-5
Women’s
Elina Svitolina (UKR x8) bt Daria Gavrilova (AUS) 7-5, 6-0
Madison Brengle (USA) bt Markéta Vondroušová (CZE x16) 6-4, 6-4
Karolina Pliskova (CZE x3) bt Zhu Lin (CHN) 6-2, 7-6 (7/4)
Simona Halep (ROM x7) bt Aliaksandra Sasnovich (BLR) 6-4, 7-5
Madison Keys (USA x17) bt Luksika Kumkhum (THA) 6-3, 6-2.
