Isco is set to start for Real Madrid against Atletico Madrid in the Champions League semi-final first leg on Tuesday night.
The midfielder is understood to be getting the nod ahead of James Rodriguez and Marco Asensio with Gareth Bale out injured.
Zinedine Zidane will revert to the same team that knocked Bayern Munich out of the Champions League at the quarter-final stage, after overseeing a 2-1 win against Valencia on Saturday.
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Isco was left on the bench at the Estadio Santiago Bernabeu as Marcelo grabbed a late winner, to give further indication that the 25-year-old will start in the first leg of the final four meeting at the same stadium on Tuesday evening.
It is understood that his recent run of good form has earned the trust of Zidane, with the Madrid manager prepared to include Isco in a front three with Cristiano Ronaldo and Karim Benzema.
Bale’s injury has allowed Zidane more room to manoeuvre when selecting his team, with Asensio coming on for Bale in El Clasico and James starting versus Valencia.
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Against Atletico, however, it will be Isco who will reinforce Madrid’s spine playing ahead of Luka Modric, Toni Kroos and Casemiro in midfield.