There are two all EPL ties with Spurs taking on the Eagles and Man Utd hosting the Gunners.
There is one all championship tie with Bristol City playing Bolton.
There is only one non-league outfit left in the competition – Barnet.
Complete 4th Round Draw:
Arsenal v Manchester United
Crystal Palace v Tottenham
Manchester City v Burnley
Chelsea v Sheffield Wednesday/Luton Town
Millwall v Everton
Shrewsbury Town/Stoke City v Wolves
Newcastle United/Blackburn Rovers v Watford
AFC Wimbledon v West Ham
Brighton and Hove Albion v West Brom
Bristol City v Bolton Wanderers
Accrington Stanley v Derby County/Southampton
Doncaster Rovers v Oldham Athletic
Middlesbrough v Newport County
Barnet v Brentford
Portsmouth v QPR
Swansea City v Gillingham
4th-round ties will be played from January 25 to 28.